McShan lab @ Georgia Tech
The questions that keep us up at night are: How does the immune system present and recognize antigens to combat disease? What are the molecular features involved in stimulating robust and specific immune responses? How can we exploit distinct features of immune recognition to develop new treatments for disease? Our research centers on answering these important questions. Mechanisms of lipid antigen selection and presentation.
Pioneering studies have provided the motivation to understand how lipids and other antigen types are selected by CD1 from the cellular ligandome. One aspect of selection can be attributed to the identity of amino acid residues lining the pockets of the antigen binding groove of different CD1 isoforms, which impose chemical and geometric restrictions on lipid recognition. However, other cellular factors are equally important for antigen selection, such as immunological chaperones and lipid transfer proteins (LTPs). Prior to display at the cell surface, CD1 molecules are found in the endoplasmic reticulum (ER), Golgi apparatus, and endocytic compartments. CD1 molecules seem to have the ability to spontaneously bind lipids, although the efficiency of this process is unclear. There is also an open question in the field of whether immunological chaperones, such as the peptide loading complex (PLC) associated tapasin and PLC-independent TAPBPR, stabilize ligand-deficient (empty) CD1 to actively promote its assembly and lipid loading along the egress to the cell surface. Finally, a plethora of LTPs have been implicated in chaperoning and lipid loading on CD1 in various cellular compartments. Some identified LTPs include microsomal triglyceride transfer protein (MTP), GM2 ganglioside activator (GM2A), Niemann-Pick type C2 protein (NPC2), Fatty acid amide hydrolase (FAAH), and the Saposin family of proteins. There is also evidence that CD1e promotes lipid loading and exchange on other CD1 isoforms. However, the precise mechanisms by which these chaperones and LTPs stabilize and promote lipid loading/exchange on CD1 remains unknown. Discovery and structural biology of disease-associated lipid/CD1 complexes.
Hundreds of thousands of unique peptide sequences have been identified to interact with classical MHC-I complexes providing a treasure trove of putative antigens for vaccine and immunotherapy development. In contrast, only hundreds of antigens have been identified to associate with CD1 molecules. Thus, the first sub-aim of this project is to discover novel lipids, lipid-like molecules, lipopeptides, natural products, and small molecule antigens presented by different CD1 isoforms. We will apply complementary approaches for antigen discovery, such as in silico screening of virtual lipid, natural product, and small molecule libraries, in vitro screening of lipid extracts from diseased cells against recombinant CD1 molecules, and in situ screening of lipids eluted directly from CD1 expressing cells using mass spectrometry. Following identification of ligands, we will probe their biological function and usefulness as drug targets by characterizing their T cell activation properties. The identification of new CD1 antigens will contribute to a broader understanding of the antigen repertoire presented CD1 during both steady and disease states of cells, further define the molecular rules for antigen recognition by CD1, and provide new targets for CD1-mediated therapeutics. T cell recognition and receptor engineering.
T cell recognition of lipid/CD1 molecules is one of the primary ways in which the immune system recognizes and responds to disease. Studies on T cell mediated immunity have for the most part focused on the activation of αβ T cells by classical peptide/MHC-I complexes. However, in recent years, αβ, γδ and NK T cells have been shown to recognize lipid/CD1 complexes to fight disease. Based on a handful of available X-ray structures, various mechanisms for TCR and KIR recognition have been proposed. To provide novel insights into receptor recognition of lipid antigens, this project aims 1) define T cell repertoires and 2) elucidate molecular docking mechanisms and antigen specificity for disease-relevant αβ, γδ and other receptor/antigen/CD1 complexes. These experiments will contribute to understanding the fundamental principles underpinning CD1 restricted antigen recognition by diverse classes of T cells. These studies will also enable us to characterize differences in T cell repertoires between healthy and diseased individuals and to provide a molecular blueprint for the development of αβ, γδ and NK T cell mediated immunotherapies.
Andrew McShan, Ph.D. Miriam Simma Ruoqing Jia Zoey Yang Lizzie Corbin Ji Yoon Jung Shreyaa Srinivasan Maya Kahn Prashanth Rathakrishnan Klara Choi Claire Tharp Aubrielle Cunningham Marielle Frooman Scripts and software developed by our lab will be shared in the future! Stay tuned. Here are fun resources we've compiled over the years. A lot of it focuses on how science, math, and art can integrate together to elucidate the beauty of nature. We hope you find something that sparks your interest.
At a minimum the McShan lab pledges to: Educate ourselves about justice and systemic discrimination against marginalized communities. Listen to and uplift voices from these communities even when they challenge our assumptions and make us uncomfortable. Speak out and push for change when we see microaggressions or institutional policies that disadvantage these communities, both within our lab and within the larger Georgia Tech community. Make space and time for trainees to heal, take care of their communities, fight for justice, and provide financial, career, and other support while they do so. Donate whenever possible to organizations that promote the success and well-being of marginalized communities in STEM or in the larger community. Examples include (but are not limited to): Fellowship for the Future by 500 Women Scientists Society for Advancement of Chicanos/Hispanics and Native Americans in Science We are extremely grateful to the following funding institutions and agencies: We love to hear from anyone who is interested in our research. Previous experience in biochemistry is beneficial, but not required. All levels of experience are welcome! The McShan lab is physically located in the Molecular Sciences and Engineering ("MoSE") building on the Georgia Institute of Technology campus in Atlanta, Georgia.Molecular and Structural Biology of Lipid Antigens in Immunity and Immunotherapy
home.
Welcome to the McShan Lab at Georgia Tech!
We focus on the CD1 family of major histocompatibility complex class I (MHC-I) related proteins, which present both self and foreign lipids to αβ, γδ, and natural killer T cells. Examples of CD1 complexes involved in the adaptive and innate immune response to human disease include those associated with lipids derived from cancerous cells (Leukemia, Carcinoma, Lymphoma, Melanoma), wasp/bee venom including yellowjackets of the genus Vespula who represent Georgia Tech's mascot Buzz (Hymenoptera venom allergy), bacterial pathogens (Mycobacterium tuberculosis - Tuberculosis, Borrelia burgdorferi - Lyme Disease, Pseudomonas aeruginosa - Pneumonia), viral pathogens (HSV-1 - Herpes, HBV - Hepatitis B), marine sponges, and self cells in autoimmune disease (Dermatitis, Psoriasis, Lysosomal Storage Disease). Recent studies have shown that CD1 can also associate with and present a much broader range of antigens, such as skin oils that lack a discernible hydrophilic head group, lipopeptides, and non-lipid small molecules. Unlike peptide antigen presentation by high polymorphic human MHC-I complexes for which therapeutics must be tailored to a patients genetic background, the non-polymorphic nature of CD1 means that lipid/CD1 molecules are attractive candidates for donor-unrestricted (i.e. universal and patient-haplotype independent) vaccines and immunotherapy treatments. Progress in the development of lipid/CD1 mediated therapies has been hindered by an incomplete understanding in several important features of the CD1 antigen processing and presentation pathway as well as a lack of structural information for clinically relevant lipid/CD1 complexes. We aim to address these knowledge gaps with our research.
Our goals are to i. understand how lipid antigens are selected and loaded onto CD1 molecules in various cellular compartments, ii. solve macromolecular structures of CD1 complexes with different disease-associated lipids antigens, iii. characterize how T cell receptors engage lipid/CD1 molecules towards activation of the immune response, iv. design lipid-based sensors of disease, and v. engineer T cell receptors (TCRs) and chimeric antigen receptors (CARs) with enhanced affinity and specificity for lipid/CD1 complexes to eliminate diseased cells. With structure, function, and design principles in hand, we become uniquely situated to develop novel immunotherapies targeting lipids associated with tumor cells, pathogen infected cells, or autoreactive cells.
The video below is a great introduction into how antigen presentation can be exploited for immunotherapy. While it focuses on classical peptide/MHC-I molecules, the approach directly translates to lipid/CD1 complexes. Credit to Dr. Samir Khleif of the Georgetown Lombardi Comprehensive Cancer Center.
The McShan lab is not focused on any particular approach or technique, although we are particularly fond of solution nuclear magnetic resonance (NMR) spectroscopy. We strive to solve outstanding biological questions with relevance to immunology, medicine, and pathology. Trainees joining our lab will gain hands on experience in biochemical/biophysical characterization of protein-protein and lipid-protein interactions (surface plasmon resonance, isothermal titration calorimetry, hydrogen/deuterium exchange mass spectroscopy), structural biology (solution NMR, X-ray crystallography, cryo-electron microscopy), computational biology (Rosetta modeling, molecular dynamics simulations), protein design/engineering, chemical biology, and immunological assays.
Illustration by Dr. McShan depicting our mascot Buzz cheering on an NMR spectrometer.
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social media.
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research.
The primary bottleneck to understanding antigen selection and loading on CD1 is the complete lack of structural information for chaperone or LTP interaction with CD1. Thus, the aim of this research project is to decipher the molecular mechanisms by which immunological chaperones and LTPs contribute to lipid antigen selection, loading and exchange on CD1. We will apply our expertise to provide structural and functional insights into these important interactions. Our studies will also expand upon the role of lipid antigens in human health as deficiencies in many LTPs result in lipid storage diseases (MTP - Abetalipoproteinemia, GM2A - GM2-gangliosidosis aka Tay-Sachs and Sandhoff disease, NPC2 - Niemann-Pick disease, FAAH - Fatty acid hydroxylase-associated neurodegeneration, Saposins - Metachromatic leukodystrophy and Gaucher disease).
Discovery of antigens is an essential and important first step. The second sub-aim of this project is to use complementary structural biology techniques, such as cryo-EM, X-ray crystallography, and solution NMR, towards determining macromolecular structures of antigen/CD1 complexes. Our solved structures will allow us to characterize in detail the molecular interactions between antigens and the CD1 groove. Our structures will also illuminate which surface(s) of the antigen are presented to TCRs and natural killer cell immunoglobulin-like receptors (KIRs). The black and white image on the right side of the page is an example structure of the lipid/CD1 antigen binding groove (PDB ID 1UQS), where the bacterial glycolipid is represented as spheres and CD1 is shown as a cartoon.
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team.
Principal Investigator
Assistant Professor
School of Chemistry and Biochemistry
Molecular Sciences and Engineering Building (MoSE)
Georgia Institute of Technology
E-mail: andrew.mcshan@chemistry.gatech.edu
Office location: MoSE G022
Office Phone #: (404) 385-6052
Pronouns: They/them
Andrew is queer, non-binary structural biologist and immunologist. They joined the faculty at Georgia Tech as an Assistant Professor in the School of Chemistry and Biochemistry in Summer 2022. They are featured on 500 queer scientists. Previously, they were a postdoctoral fellow in the lab of Dr. Nikolaos Sgourakis at the Children's Hospital of Philadelphia & The University of Pennsylvania (2020-2022) studying antigen presentation of classical peptide/MHC-I molecules. Before that, they were also with Dr. Sgourakis at the University of California, Santa Cruz (2016-2020). They also worked as a biotechnology intern in the lab of Y. John Wang at Genentech (2015). They obtained their Ph.D. in Molecular, Cellular & Developmental Biology at the University of Kansas in the lab of Dr. Roberto De Guzman (2011-2016) studying bacterial type III section systems. They carried out undergraduate research in epigenetics (also at KU) in the lab of Dr. Justin Blumenstiel.
You may find Dr. McShan at:
Twitter
LinkedIn
Google Scholar
In their spare time they love to watch anime, partake in collaborative theatre adventures with their wife, make curated Spotify playlists, and create music under the moniker Emo Side Project.
Graduate Students
Pronouns: She/her
Ph.D. student, Chemistry and Biochemistry
I am from Dacula, GA and did my undergraduate degree at Oglethorpe University in Chemistry with research in the Walden lab. My research in the McShan lab involves understanding how proteins associate with lipids towards their role in immunological signaling and rare lipid storage disorders. In my free time I like lifting weights, traveling, going to Hogwarts, and eating good food.
Pronouns: She/her
Ph.D. student, Chemistry and Biochemistry
I completed my undergraduate study in Nutritional Science and Chemistry at Pennsylvania State University and come to continue my education here at the Georgia Institute of Technology. My research in McShan Lab focuses on studying different lipid transfer proteins towards solving their atomic structures and mechanisms of action. Outside the lab, I am a big Disney fan. I have a Little Mermaid tattoo! I have been to all of the Disney parks around the world. So far, I think DisneyWorld is the best.
Pronouns: She/her
Ph.D. student, Bioinformatics
I completed my undergrad in pharmacy at Taipei Medical University in Taiwan and pursued my Master's in computational biology at Carnegie Mellon University. My research in the McShan lab involves developing and applying computational biology methods to understand protein/protein and lipid/protein interactions, and to design new protein therapeutics. Outside of the lab, I enjoy music, surfing, scuba diving, traveling, and playing with cute animals.
Pronouns: She/her
Ph.D. student, Chemistry and Biochemistry
I am from Orlando, FL and completed my Bachelor's in biological sciences at Florida State University. Recently, I completed my Master's in biology here at Georgia Tech. In the McShan lab, I am using structural biology to answer fundamental questions about the adaptive and innate immune systems and towards discovery of novel antigens. Outside of lab, I enjoy sports, Disney World, and adventuring around Georgia.
Pronouns: She/her
Master's student, Biomedical Engineering
I was born in Seoul, Korea, but grew up in Shanghai, China, and got my Bachelor’s in Houston, TX. I did my undergraduate research in the lab of Dr. Aryeh Warmflash at Rice University (2018-2021) studying morphogens in human gastruloids. In the McShan lab, I am designing proteins to inhibit pathogen infection for next-generation therapeutics. Outside of research, I enjoy playing board games, reading books, and decorating my bullet journal.
Pronouns: She/her
Master's student, Biomedical Engineering
I did my undergraduate studies in Biotechnology in India and worked as a research assistant in Indian Institute of Science. After that I worked as a junior scientist for a Biotech start-up company called KoshKey. In the McShan lab, I am using experimental and computational tools towards immunoengineering T-cell receptors and antigens presented by MHCs. Outside the lab, I enjoy playing board games, hiking and watching Netflix shows and movies.
Undergraduates
Pronouns: She/her
Undergraduate student, Biochemistry major
I am from Dunwoody, GA. I love doing research and have previously worked in a microbiology lab. I also spent a summer working for The Mediterranean Food Lab, a food tech startup that focuses on meat alternatives. In the McShan lab, my research involves characterizing immune responses to Malaria using structural biology methods. Outside of the lab, I love playing volleyball and guitar. I am passionate about learning languages; I already speak three and hope to learn more!
Pronouns: He/him
Undergraduate student, Biology major
I am from Duluth, GA. I am interested in the biology of the immune system at the molecular level. In the McShan lab, my research involves characterizing antigen repertoires of CD1 immunoreceptors using computational biology approaches. Outside of the lab, I love to volunteer at healthcare facilities, explore the city, and listen to music.
Pronouns: She/her
Undergraduate student, Biology major
I am from Alpharetta, GA. In the McShan lab, my research involves characterizing immune responses to Malaria using structural biology methods. Outside of the lab and school, I enjoy reading books, spending time in animal shelters, and volunteering with mobile health clinics.
Pronouns: She/her
Undergraduate student, Biochemistry major
I am from Decatur, GA. In the McShan lab, my research involves examining how certain proteins associate with lipids in relation to their role in immunological signaling. Outside of the lab, I enjoy reading, volunteering in animal shelters, and bingeing TV shows.
Pronouns: She/her
Undergraduate Student, Forensic Science (at Savannah State University)
I'm a summer 2023 REU student in Chemistry and Biochemistry at Georgia Tech. I am from Wilkes Barre, Pennsylvania. My research in McShan lab involves using biochemistry and structural biology to understand immune responses to Malaria. In my free time I enjoy shopping, traveling, and hanging with friends.
Pronouns: She/her
Undergraduate student, Biochemistry major
I am from right here in Atlanta! Before coming to Tech, I performed a yearlong study on the teratogenic effects of chronic gestational caffeine exposure. Now, in the McShan lab, I am using structural biology to better understand immune responses to malaria. Outside of the lab, you’ll usually find me walking around campus shamelessly playing Pokémon go.
Previous Members / Alumni
Jenna RisCassi, Undergraduate Student, Spring 2023
Current Position: Master's student in Analytical Chemistry at Georgia Institute of Technology (as of Fall 2023)
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publications.
See below for a full list of our peer reviewed publications:
McShan Lab Publications @ Google Scholar
* These authors contributed equally to this work.
# Co-corresponding authors.
Bold = McShan lab member
Publications while at the Georgia Institute of Technology
22. Zhong W*, Deutsch JM*, Yi D, Abrahamse NH, Mohanty I, Moore SG, McShan AC, Garg N, Agarwal V. Discovery and biosynthesis of ureidopeptide natural products macrocyclized via indole N-acylation produced by marine Microbulbifer spp. bacteria. ChemBioChem e202300190, 2023
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21. McShan AC. Utility of methyl side chain probes for solution NMR studies of large proteins. Journal of Magnetic Resonance Open 14–15, 100087, 2023
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Publications while at the Children's Hospital of Philadelphia / University of Pennsylvania (Sgourakis lab)
20. McShan AC, Devlin CA, Papadaki GF, Sun Y, Green AI, Morozov GI, Burslem GM, Procko E, Sgourakis NG. TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nature Chemical Biology 18, 859–868, 2022
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19. McShan AC*, Devlin CA*, Morozov GI, Overall SA, Moschidi D, Akella N, Procko E#, Sgourakis NG#. TAPBPR Promotes Loading of Cargo on MHC-I Molecules Using a Peptide Trap. Nature Communications 12, 3174, 2021
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18. Nerli S*, De Paula VS*, McShan AC, Sgourakis NG. Backbone-independent NMR resonance assignments of methyl probes in large proteins. Nature Communications 12, 691, 2021
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Publications while at the University of California, Santa Cruz (Sgourakis lab)
17. Koehler Leman J*, Weitzner BD*, Renfrew PD, Lewis, SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, RosettaCommons Consortium (including McShan AC), Bystroff C, Schief W, Gront D, Schueler-Furman O, Baker D, Bradley P, Roland Dunbrack R, Kortemme T, Leaver-Fay A, Strauss CE, Meiler J, Kuhlman B, Gray JJ, and Bonneau R. Better together: Elements of successful scientific software development in a distributed collaborative community. PLOS Computational Biology 16(5):e1007507, 2020
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16. Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. PNAS 117(13):7208-7215, 2020
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15. Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. De novo design of a homo-trimeric amantadine-binding protein. eLife 8. pii: e47839, 2019
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14. McShan AC*, Devlin CA*, Overall SA, Park J, Toor JS, Moschidi D, Flores-Solis D, Choi H, Tripathi S, Procko E#, Sgourakis NG#. Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. PNAS 116(51):25602-25613, 2019
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13. Marceau AH*, Brison C*, Nerli S*, Arsenault HE, McShan AC, Chen E, Lee HW, Benanti JA, Sgourakis NG, Rubin SM. An order-to-disorder structural switch activates the FoxM1 transcription factor. eLife 8. pii: e46131, 2019
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12. Marcos E, Chidyausiku TM, McShan AC, Evangelidis T, Nerli S, Carter L, Nivon LG, Davis A, Oberdorfer G, Tripsianes K, Sgourakis NG, Baker D. De novo design of a non-local β-sheet protein with high stability and accuracy. Nature Structural and Molecular Biology 25(11):1028-1034, 2018
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11. McShan AC, Natarajan K, Kumirov VK, Flores-Solis D, Jiang J, Badstubner M, Toor JS, Bagshaw CR, Kovrigin EL, Margulies DH, Sgourakis NG. Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle. Nature Chemical Biology 14(8):811-820, 2018
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10. Natarajan K, Jiang J, May NA, Mage MG, Boyd LF, McShan AC, Sgourakis NG, Bax A, Margulies DH. The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling. Frontiers in Immunology 9:1657, 2018
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9. Nerli S, McShan AC, Sgourakis NG. Chemical shift-based methods in NMR structure determination. Progress in Nuclear Magnetic Resonance Spectroscopy 106-107, 2018
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8. Toor JS, Rao AA, McShan AC, Yarmarkovich M, Nerli S, Yamaguchi K, Madejska AA, Nguyen S, Tripathi S, Maris JM, Salama SR, Haussler D, Sgourakis NG. A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Frontiers in Immunology 9:99, 2018
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7. Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG. An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role. Nature Communications 16;8:15260, 2017
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Publications while at Genentech (Wang lab)
6. McShan AC, Kei P, Ji JA, Kim DC, Wang YJ. Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases. PDA Journal of Pharmaceutical Science and Technology 70(4):332-45, 2016
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Publications while at the University of Kansas (De Guzman lab)
5. McShan AC, Kaur K, Chatterjee S, Knight KM, De Guzman RN. NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions. Proteins 84, 1097-1107, 2016
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4. McShan AC, Anbanandam A, Patnaik S, De Guzman RN. Characterization of the Binding of Hydroxyindole, Indoleacetic acid and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB. ChemMedChem 11, 963-971, 2016
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3. McShan AC, De Guzman RN. The bacterial type III secretion system as a target for developing new antibiotics. Chemical Biology and Drug Design 85(1):30-42, 2015
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2. Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN. NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. Journal of Molecular Biology 12;426(16):2958-69, 2014
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1. Chatterjee S, Chaudhury S, McShan AC, Kaur K, De Guzman RN. Structure and biophysics of type III secretion in bacteria. Biochemistry, 52(15):2508-17, 2013
[read]
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structure gallery.
Below is a gallery of structures solved by our lab, either independently or through collaborative efforts with other labs. We love to solve macromolecular structures because they inform scientists of biological function, provide important insights into disease, and open new avenues for drug development.
You must have WebGL enabled to view the structures
3Dmol is used for visualization.
Left click to rotate.
Use the scroll wheel to zoom in or out.
Press and hold the scroll wheel or control to move up or down.
Ac-6-FP/MR1/TAPBPR structure - PDB ID 7RNO
Solved while in the Sgourakis lab (UPENN/CHOP)
Function: Metabolite antigen presentation
NRASQ61K/HLA-A*01:01 structure - PDB ID 6MPP
Solved in the Sgourakis Lab together with David Flores-Solis (UC Santa Cruz)
Function: Neoepitope antigen presentation in neuroblastoma
Computationally designed protein XAA - PDB ID 6O0I
Solved in the Sgourakis lab together with Danai Moschidi and Santrupti Nerli (UC Santa Cruz)
Collaboration with Kathy Wei in the Baker lab (UW)
Function: De novo designed protein
Disulfide linked P18-I10/H2-Dd - PDB ID 6NPR
Solved in the Sgourakis lab together with Joey Toor and Sarvind Tripathi (UC Santa Cruz)
Function: Peptide antigen presentation
FoxM1 transcription factor - PDB ID 6OSW
Solved in the Sgourakis Lab together with Santrupti Nerli (UC Santa Cruz)
Collaboration with Aimee Marceau in the Rubin lab (UC Santa Cruz)
Function: Cancer associated transcription factor
De novo designed double-stranded beta-helix - PDB ID 6E5C
Solved in the Sgourakis Lab together with Santrupti Nerli (UC Santa Cruz)
Collaboration with Enrique Marcos in the Baker lab (UW)
and Thomas Evangelidis in the Tripsianes lab (CEITEC)
Function: De novo designed protein
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resources.
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learn.
Below are resources to learn about macromolecule structures and the experimental techniques commonly used by our lab.
I am also providing other learning resources useful to researchers in STEM fields.
*The CD1 family: serving lipid antigens to T cells since the Mesozoic era introduction to CD1
* 5 challenges we could solve by designing new proteins by David Baker
* AlphaFold: The making of a scientific breakthrough
*iBiology interesting and state-of-the-art science lectures
*Ask a Scientist Gaming hosted by Kenneth Hanson where video games and science collide
*ICMBRS Webinars biomolecular NMR lectures
*Protein Folding and Dynamics Webinars lectures on protein folding and dynamics
*Global NMR Discussion Meetings biomolecular NMR lectures
*Getting Started in Cryo-EM tutorial by Grant Jensen
*Basics of Macromolecular Crystallography by Andrea Thorn
*Learn Rosetta computational biomolecular modeling tutorials
*Walter Bauer nmr spectroscopy meets music
*Frank Delaglio lecture on nmr processing in nmrpipe
*The Science of Mentorship Podcast introduction to inclusive, equity minded mentoring in STEM
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teaching.
Dr. McShan's Lectures and Presentations
Women+ in Chemistry Spring 2023 Retreat Lecture slides:
"Research Based Lessons for Effective Mentor/Mentee Relationships in STEM"
Teaching at Georgia Tech
Fall 2023 - CHEM 3521/CHEM 6501 - Biochemistry I
Fall 2022 - CHEM 6501 - Biochemistry I
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fun.
numbers:
*3D-XplorMath. open source software for topological surface visualization
virtual math museum gallery of shapes and surfaces made using 3D-XplorMath
*46 billion pixel panorama image of the Milk Way galaxy astronomy
a:
*Susan Aldworth website science based art, illustration, etching, mixed media
*Rafael Araujo website math based art, illustration, landscapes
*art for science science journal and book illustrations
*The Aquabats! - Doing Science! music
b:
*BALLView website biomolecular visualization software
*Michele Banks website science based art, biology, watercolor, collage
*Tom Beddard website math based art, fractals, 3D
*Drew Berry Bjork - Hollow 3d biology animation for a Bjork video
*Luc Benard collaboration with Richard Palais
*BioBlender open source software for 3D rendering with science applications
*Paul Bourke website math based art, simulations, etc.
*Caroline Bowen website math and physics based art
*Kelsey Brookes website science based art, biochemistry, pop, abstract, psychedelic
*Roger Brown website science based art, paper sculptures
c:
*Santiago Calatrava website science and math based architecture and engineering, ceramics, sculpture, drawings
*Jonathan Callan website using books and paper as a sculptural medium
*Alexander Calder website sculpture, abstract
Calder and abstraction: from avant-garde to iconic
*Joey Camacho website science based art, 3D motion and graphic design
*Camila Sitarama Carlow website science based art, nature, mixed media
*George F. Chambers list of books as pdf vintage astronomy illustrations
*Chaoscope website software for math based rendering and dynamic systems
*Julie Alice Chappell website science based art
*Chemistry in pictures website science, photography
*William Chyr website science based art, sculpture, balloons
*Andreas Cellarius some of his works vintage astronomy illustrations, cartography
check out Harmonia Macrocosmica
*Chemical Bouillon website science based art, chemical reactions, video, patterns and abstract shapes
*Dale Chihuly website abstract, glass work
*Caleb Charland website abstract
*Anita Chowdry website math based art, paper sculptures, abstract, etching, geometry
*Francesco de Comite website math based art, geometry, 3D printing
flickr
*Jean Constant website math based art, topology
*Justine Cooper website science based art
*Pedro Cruz website science based art, creative coding, generative art
d:
*Erik Demaine website math based art, geometry, origami
*Maja Divjak vimeo science based art, molecular movies, 3D
*Katharine Dowsen website science based art, sculpture, glass work
*Greg Dunn website science based art, neuroscience, etching, scrolls
e:
*James R. Eads website abstract, illustration
*Maria Clara Eimmart some examples vintage astronomy illustrations
*Olafur Eliasson website sculpture, light/color
*M.C. Escher website math based art, abstract, multimedia
*Engineering at Cambridge University flickr science based art and photography, check out their photography competitions
*EteRNA RNA folding game, software
f:
*Sarah Featon website scientific illustration, botany
*Fold It! biochemistry and protein folding game, software
*Anatoly Fomenko website math based art, abstract
*Lucio Fontana artsy abstract, painting, graphic design
*R. Buckminster Fuller artsy architecture, geometry, engineering
g:
*Fred Gambino website science fiction, concept design, animation
*Eleanor Gates-Stuart website science based art
*Giant Microbes science based art, plush microbes
*Steve Gildea website science based art, space art, painting, drawing, 3D
*Linden Gledhill website science based art, abstract
*Andy Goldsworthy visual melt science based art, nature, symmetry
*David Goodsell website science based art, biology illustrations, proteins and organisms
*Akinori Goto tumblr media art
*Bathsheba Grossman website science based art, sculpture, laser crystals, glass work
h:
*Ernst Haeckel art forms in nature vintage biology illustrations
*Bradford Hansen-Smith website math based art, sculpture, paper sculpture
*George W. Hart website math based art, sculpture, design
*Stuart Haygarth website math based art, sculpture, abstract
*HEBOCON HEBOCON: The Robot Contest for Dummies engineering
*Patrik Huebner website math based art, creative coding, generative design
*Jonty Hurwitz website science and math based art, abstract, nanosculptures
i:
*Iconographic Encyclopedia of Science, Literature and Art vintage science illustrations
* The Institute For Figuring website creative engagements with topology, physics, computation and biology
crochet coral reef crochet, marine biology
*Interactions Image Bank website image databank of physics stuff. particle collision images are particularly beautiful.
*Ig Nobel Prize abstract and interesting research
j:
*Wenzel Jamnitzer BibliOdyssey vintage math based art, symmetry, etching
*Christopher Janney website math based art, architecture, sound
*Luke Jerram website science based art, biology, glass work, multimedia
*Brian Johnston views through a mathematical microscope of some 3D oddities
*Janusz Jurek website math based art, illustration, sculpture
behance
k:
*Markos R. Kay website science based art, 3d motion graphics, simulations, prints
check out aDiatomea
*Ikumi Kayama website science based art, illustration
*Alexey Kashpersky website science based art, digital art, 3D, photography
*Dinara Kasko website architectural, geometry, gastronomy
*Melanie Kathryn-King website science based art, illustration, photography
*Charles Knight website vintage biology art, dinosaurs
*Stephen R. Kutcher website science based art, art using insects, painting
*Martin Krzywinski website science based art, data visualization
l:
*Robert J. Lang website origami
*Kenneth Libbrecht website science based art
check out snow crystals
*Emma Lindstrom website painting
*Richard Long website math and science based art, nature, symmetry, sculpture, drawing
*Lorem Ipsum tumblr creative coding, generative art, abstract
*Marcus Lyon website design, photography
*The Lumen Prize website art generated by technology
*Eleanor Lutz website scientific illustration
m:
*Benoit Mandelbrot Mandelbrot set. fractals, geometry
*Friedrich Heinrich Wilhelm Martini shell prints vintage science illustration
*Oliver Marsden website math based art, abstract, painting, illustration, prints
*melodysheep Symphony of science science topic based music
check out a glorious dawn a tribute to carl sagan
*Nathalie Miebach website science art, abstract, music, sculpture
*Steve Miller website science based art, sculpture, painting
*Hine Mizushima website science based art, felt
*Anne Mondro website sculpture
n:
*NASA science
NASA project apollo archive space photography
astronomy picture of the day large library of space photography
*Neurobureau brain art gallery science based art, neuroscience
*Odra Noel Odra Noel science based art
*Nikon Small World in Motion youtube channel science based art, microscopy, photography
*Paul Nylander website math and physics based art
o:
*Nuala O'Donovan website math based art, sculpture, ceramics, abstract
*Fabian Oefner website science based art, paint, multimedia
*Neri Oxman website science based art, 3d printed fashion, sculpture
p:
*Pacific Northwest National Laboratory flickr check out their science as art section
*Kate Patterson youtube science based art, molecular movies, 3D
*J. C. Park website science fiction, concept, design
*Sui Park website sculpture
*The Particle Zoo website science based art, plush dolls of fundamental particles, particle physics
*PhD Comics website comics, humor for graduate students
*Princeton University art as science galleries
*Processing open source software for creative coding and generative art
open processing sharing of sketches and code made using Processing
*PyMol open source software for 3D visualization and rendering of proteins and molecules
*Helen Pynor website science based art, sculpture, illustration
q:
r:
*Sabine Reckewell website design, sculpture
*Ribosome dance Protein synthesis: an epic on the cellular level biochemistry
*Jane S. Richardson Biophysical Highlights from 54 Years of Macromolecular Crystallography science illustration, biochemistry (particularly beta-sheet containing proteins)
website
*Michael Rigley website math and science based art, 3D, animation, design
*Bridget Riley gallery of her works math based art, op art
*Anthony Roussel website math based art, jewelry, digital art
s:
*Tomas Saraceno website math and science based art, architecture
*SASJ website creative coding, generative art, geometry, shapes, game design
*Science-Art databank of science based art, mostly nature and medical illustration
*Nina Sellars website science based art, 3D
*James B. Settles some of his works vintage science fiction illustrations
*Alyson Shotz website math based art, architecture, sculpture
*Oleg Soroko behance math based art, architecture, sculpture, abstract
*Susi Sie website science and math based videos, abstract
*JR Bee website science based illustration
*Claudia Stocker website science based art, illustration
*Nils Henrik Sundqvist website science based art, illustration, design, prints
t:
*P. G. Tait check out the 'On Knots' series vintage math illustrations, knot theory
*Jared Tarbell website science and math based art, creative coding, generative art, photography
flickr
*Steve Tobin website math based art, sculpture, abstract, glass work, steel work
*Anais Tondeur website science based art, space art, drawing
u:
*Julijonas Urbonas website engineering, math
*UCSF RBVI Holiday Card Gallery website biochemistry, holiday cards
v:
*Van Cleef & Arpels Midnight Planetarium timepiece astronomy, watch
*Roman Verostko website math based art, illustrations, generative art
*Arie van't Riet website science based art, photography, x-ray images
*Julian Voss-Andreae website sculpture
w:
*Elise Wagner website science based art, painting, wax, abstract
*WeatherStar 4000 simulator website meteorology, simulation
*Wintergatan Marble Machine engineering, music
x:
y:
*Motoi Yamamoto website media art, installation
z:
*Doug Zongker chicken chicken chicken lecture what watching an academic lecture feels like sometimes
what reading an academic paper feels like sometimes
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DEI values.
The McShan lab is committed to maintaining an inclusive research environment, regardless of age, gender, gender identity, sexual orientation, disability, race, religion, nationality, immigration status, or socio-economic background.
The poster and pledge have been derived from images and words by Sammy Katta.
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funding.
Georgia Tech's School of Chemistry and Biochemistry - Start up funds
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join us.
We openly welcome members of the LGBTQAI+ community, women, disabled scientists (including those with invisible disabilities), and scientists of color.
Prospective graduate students should first apply to Georgia Tech's Chemistry and Biochemistry Graduate Program. You can apply here: Graduate Admission @ Georgia Tech's Chemistry and Biochemistry program. Accepted students should feel free to reach out and discuss opportunities in our lab.
Due to funding limitations, the lab is currently not accepting Postdoctoral Fellows. If you want to pursue a Postdoctoral Fellowship in the lab and have your own funding, please feel free to reach out.
Undergraduates and high school students interested in getting hands on experience with research should also reach out to us at andrew.mcshan@chemistry.gatech.edu
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contact.
Please contact us via e-mail at andrew.mcshan@chemistry.gatech.edu
Office location: MoSE G022
Office Phone #: (404) 385-6052
Lab location: MoSE G125
901 Atlantic Drive NW
Atlanta, GA 30332-0400
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Dr. Andrew McShan
901 Atlantic Drive NW
School of Chemistry and Biochemistry
Georgia Institute of Technology
Atlanta, GA 30332-0400
Send UPS and FedEx deliveries to:
Dr. Andrew McShan
311 Ferst Drive NW
School of Chemistry and Biochemistry
Georgia Institute of Technology
Atlanta, GA 30332-0400
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Georgia Institute of Technology
School of Chemistry & Biochemistry
Website design by Dr. McShan
