McShan lab @ Georgia Tech

Molecular and Structural Biology of Lipid Antigens in Immunity and Immunotherapy



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Welcome to the McShan Lab at Georgia Tech!


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The questions that keep us up at night are: How does the immune system present and recognize antigens to combat disease? What are the molecular features involved in stimulating robust and specific immune responses? How can we exploit distinct features of immune recognition to develop new treatments for disease? Our research centers on answering these important questions.

We focus on the CD1 family of major histocompatibility complex class I (MHC-I) related proteins, which present both self and foreign lipids to αβ, γδ, and natural killer T cells. Examples of CD1 complexes involved in the adaptive and innate immune response to human disease include those associated with lipids derived from cancerous cells (Leukemia, Carcinoma, Lymphoma, Melanoma), wasp/bee venom including yellowjackets of the genus Vespula who represent Georgia Tech's mascot Buzz (Hymenoptera venom allergy), bacterial pathogens (Mycobacterium tuberculosis - Tuberculosis, Borrelia burgdorferi - Lyme Disease, Pseudomonas aeruginosa - Pneumonia), viral pathogens (HSV-1 - Herpes, HBV - Hepatitis B), marine sponges, and self cells in autoimmune disease (Dermatitis, Psoriasis, Lysosomal Storage Disease). Recent studies have shown that CD1 can also associate with and present a much broader range of antigens, such as skin oils that lack a discernible hydrophilic head group, lipopeptides, and non-lipid small molecules. Unlike peptide antigen presentation by high polymorphic human MHC-I complexes for which therapeutics must be tailored to a patients genetic background, the non-polymorphic nature of CD1 means that lipid/CD1 molecules are attractive candidates for donor-unrestricted (i.e. universal and patient-haplotype independent) vaccines and immunotherapy treatments. Progress in the development of lipid/CD1 mediated therapies has been hindered by an incomplete understanding in several important features of the CD1 antigen processing and presentation pathway as well as a lack of structural information for clinically relevant lipid/CD1 complexes. We aim to address these knowledge gaps with our research.

Our goals are to i. understand how lipid antigens are selected and loaded onto CD1 molecules in various cellular compartments, ii. solve macromolecular structures of CD1 complexes with different disease-associated lipids antigens, iii. characterize how T cell receptors engage lipid/CD1 molecules towards activation of the immune response, iv. design lipid-based sensors of disease, and v. engineer T cell receptors (TCRs) and chimeric antigen receptors (CARs) with enhanced affinity and specificity for lipid/CD1 complexes to eliminate diseased cells. With structure, function, and design principles in hand, we become uniquely situated to develop novel immunotherapies targeting lipids associated with tumor cells, pathogen infected cells, or autoreactive cells.

The video below is a great introduction into how antigen presentation can be exploited for immunotherapy. While it focuses on classical peptide/MHC-I molecules, the approach directly translates to lipid/CD1 complexes. Credit to Dr. Samir Khleif of the Georgetown Lombardi Comprehensive Cancer Center.


The McShan lab is not focused on any particular approach or technique, although we are particularly fond of solution nuclear magnetic resonance (NMR) spectroscopy. We strive to solve outstanding biological questions with relevance to immunology, medicine, and pathology. Trainees joining our lab will gain hands on experience in biochemical/biophysical characterization of protein-protein and lipid-protein interactions (surface plasmon resonance, isothermal titration calorimetry, hydrogen/deuterium exchange mass spectroscopy), structural biology (solution NMR, X-ray crystallography, cryo-electron microscopy), computational biology (Rosetta modeling, molecular dynamics simulations), protein design/engineering, chemical biology, and immunological assays.

Approach /

Illustration by Dr. McShan depicting our mascot Buzz cheering on an NMR spectrometer.


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news.




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research.


Mechanisms of lipid antigen selection and presentation.


Pioneering studies have provided the motivation to understand how lipids and other antigen types are selected by CD1 from the cellular ligandome. One aspect of selection can be attributed to the identity of amino acid residues lining the pockets of the antigen binding groove of different CD1 isoforms, which impose chemical and geometric restrictions on lipid recognition. However, other cellular factors are equally important for antigen selection, such as immunological chaperones and lipid transfer proteins (LTPs). Prior to display at the cell surface, CD1 molecules are found in the endoplasmic reticulum (ER), Golgi apparatus, and endocytic compartments. CD1 molecules seem to have the ability to spontaneously bind lipids, although the efficiency of this process is unclear. There is also an open question in the field of whether immunological chaperones, such as the peptide loading complex (PLC) associated tapasin and PLC-independent TAPBPR, stabilize ligand-deficient (empty) CD1 to actively promote its assembly and lipid loading along the egress to the cell surface. Finally, a plethora of LTPs have been implicated in chaperoning and lipid loading on CD1 in various cellular compartments. Some identified LTPs include microsomal triglyceride transfer protein (MTP), GM2 ganglioside activator (GM2A), Niemann-Pick type C2 protein (NPC2), Fatty acid amide hydrolase (FAAH), and the Saposin family of proteins. There is also evidence that CD1e promotes lipid loading and exchange on other CD1 isoforms. However, the precise mechanisms by which these chaperones and LTPs stabilize and promote lipid loading/exchange on CD1 remains unknown.

The primary bottleneck to understanding antigen selection and loading on CD1 is the complete lack of structural information for chaperone or LTP interaction with CD1. Thus, the aim of this research project is to decipher the molecular mechanisms by which immunological chaperones and LTPs contribute to lipid antigen selection, loading and exchange on CD1. We will apply our expertise to provide structural and functional insights into these important interactions. Our studies will also expand upon the role of lipid antigens in human health as deficiencies in many LTPs result in lipid storage diseases (MTP - Abetalipoproteinemia, GM2A - GM2-gangliosidosis aka Tay-Sachs and Sandhoff disease, NPC2 - Niemann-Pick disease, FAAH - Fatty acid hydroxylase-associated neurodegeneration, Saposins - Metachromatic leukodystrophy and Gaucher disease).


Discovery and structural biology of disease-associated lipid/CD1 complexes.

CD1 ligands
Examples of CD1 ligands.

Hundreds of thousands of unique peptide sequences have been identified to interact with classical MHC-I complexes providing a treasure trove of putative antigens for vaccine and immunotherapy development. In contrast, only hundreds of antigens have been identified to associate with CD1 molecules. Thus, the first sub-aim of this project is to discover novel lipids, lipid-like molecules, lipopeptides, natural products, and small molecule antigens presented by different CD1 isoforms. We will apply complementary approaches for antigen discovery, such as in silico screening of virtual lipid, natural product, and small molecule libraries, in vitro screening of lipid extracts from diseased cells against recombinant CD1 molecules, and in situ screening of lipids eluted directly from CD1 expressing cells using mass spectrometry. Following identification of ligands, we will probe their biological function and usefulness as drug targets by characterizing their T cell activation properties. The identification of new CD1 antigens will contribute to a broader understanding of the antigen repertoire presented CD1 during both steady and disease states of cells, further define the molecular rules for antigen recognition by CD1, and provide new targets for CD1-mediated therapeutics.

Discovery of antigens is an essential and important first step. The second sub-aim of this project is to use complementary structural biology techniques, such as cryo-EM, X-ray crystallography, and solution NMR, towards determining macromolecular structures of antigen/CD1 complexes. Our solved structures will allow us to characterize in detail the molecular interactions between antigens and the CD1 groove. Our structures will also illuminate which surface(s) of the antigen are presented to TCRs and natural killer cell immunoglobulin-like receptors (KIRs). The black and white image on the right side of the page is an example structure of the lipid/CD1 antigen binding groove (PDB ID 1UQS), where the bacterial glycolipid is represented as spheres and CD1 is shown as a cartoon.


T cell recognition and receptor engineering.

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Taken from the National Cancer Institute website

T cell recognition of lipid/CD1 molecules is one of the primary ways in which the immune system recognizes and responds to disease. Studies on T cell mediated immunity have for the most part focused on the activation of αβ T cells by classical peptide/MHC-I complexes. However, in recent years, αβ, γδ and NK T cells have been shown to recognize lipid/CD1 complexes to fight disease. Based on a handful of available X-ray structures, various mechanisms for TCR and KIR recognition have been proposed. To provide novel insights into receptor recognition of lipid antigens, this project aims 1) define T cell repertoires and 2) elucidate molecular docking mechanisms and antigen specificity for disease-relevant αβ, γδ and other receptor/antigen/CD1 complexes. These experiments will contribute to understanding the fundamental principles underpinning CD1 restricted antigen recognition by diverse classes of T cells. These studies will also enable us to characterize differences in T cell repertoires between healthy and diseased individuals and to provide a molecular blueprint for the development of αβ, γδ and NK T cell mediated immunotherapies.


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team.


Principal Investigator
me

Andrew McShan, Ph.D.
Assistant Professor
School of Chemistry and Biochemistry
Molecular Sciences and Engineering Building (MoSE)
Georgia Institute of Technology
E-mail: andrew.mcshan@chemistry.gatech.edu
Office location: MoSE G022
Office Phone #: (404) 385-6052
Pronouns: They/them


Andrew is queer, non-binary structural biologist and immunologist. They joined the faculty at Georgia Tech as an Assistant Professor in the School of Chemistry and Biochemistry in Summer 2022. They are featured on 500 queer scientists. Previously, they were a postdoctoral fellow in the lab of Dr. Nikolaos Sgourakis at the Children's Hospital of Philadelphia & The University of Pennsylvania (2020-2022) studying antigen presentation of classical peptide/MHC-I molecules. Before that, they were also with Dr. Sgourakis at the University of California, Santa Cruz (2016-2020). They also worked as a biotechnology intern in the lab of Y. John Wang at Genentech (2015). They obtained their Ph.D. in Molecular, Cellular & Developmental Biology at the University of Kansas in the lab of Dr. Roberto De Guzman (2011-2016) studying bacterial type III section systems. They carried out undergraduate research in epigenetics (also at KU) in the lab of Dr. Justin Blumenstiel.

You may find Dr. McShan at:
Twitter
LinkedIn
Google Scholar

In their spare time they love to watch anime, partake in collaborative theatre adventures with their wife, make curated Spotify playlists, and create music under the moniker Emo Side Project.




Postdoctoral Scholars
We're a new lab so no one yet!
Interested in joining our team? Check our open positions!



Graduate Students
Interested in joining our team? Check our open positions!


uche

Uche Arunsi
Pronouns: He/him
Uche is a graduate student pursing a Ph.D. in the Chemistry and Biochemistry Department at Georgia Tech. Uche is originally from Nigeria. He is interested in the molecular interactions between CD1 proteins and lipid molecules, especially onco-lipids. He loves doing research and has previously worked in a biochemistry and molecular biology laboratories in the University of Ibadan, Nigeria, and University of Nottingham, United Kingdom. His interest in CD1 proteins stems from his Master’s program where he explored the role of Zeb1 and inflammation in the control of vessel quiescence. In the long term, he intends to acquire the skill sets needed to modify cancer patient’s immune cells and potentially trigger their death through globalized antigen-mediated T-cell signaling. Outside of the lab, Uche loves listening to classic music and seeing afro movies.



Undergraduates
Interested in joining our team? Check our open positions!


maya

Maya Kahn
Pronouns: She/her
Maya is a third-year Biochemistry major from Dunwoody, GA interested in the chemistry behind the immune system. She loves doing research and has previously worked in a microbiology lab. She also spent the summer working for The Mediterranean Food Lab, a food tech startup that focuses on meat alternatives. Outside of the lab, Maya loves playing volleyball and guitar. She is also passionate about learning languages; she already speaks three and hopes to learn more!


prashanth

Prashanth Rathakrishnan
Pronouns: He/him
Prashanth is a sophomore at Georgia Tech from Duluth, GA majoring in Biology and minoring in Health, Medicine, and Society. He is interested in the biology of the immune system at the molecular level. He is excited to work in the McShan Lab and investigate topics within these fields using computational biology approaches. Outside of the lab, Prashanth loves to volunteer at healthcare facilities, explore the city, and listen to music.


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publications.



See below for a full list of our publicaitons in peer reviewed journals:
McShan Lab Publications @ Google Scholar

* These authors contributed equally to this work.
# Co-corresponding authors.
Bold = McShan lab member


Publications while at the Children's Hospital of Philadelphia / University of Pennsylvania (Sgourakis lab)


20. McShan AC, Devlin CA, Papadaki GF, Sun Y, Green AI, Morozov GI, Burslem GM, Procko E, Sgourakis NG. TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules. Nature Chemical Biology 2022 [read]


19. McShan AC*, Devlin CA*, Morozov GI, Overall SA, Moschidi D, Akella N, Procko E#, Sgourakis NG#. TAPBPR Promotes Loading of Cargo on MHC-I Molecules Using a Peptide Trap. Nat. Commun. 12, 3174, 2021 [read]


18. Nerli S*, De Paula VS*, McShan AC, Sgourakis NG. Backbone-independent NMR resonance assignments of methyl probes in large proteins. Nat. Commun. 12, 691, 2021 [read]


Publications while at the University of California, Santa Cruz (Sgourakis lab)


17. Koehler Leman J*, Weitzner BD*, Renfrew PD, Lewis, SM, Moretti R, Watkins AM, Mulligan VK, Lyskov S, Adolf-Bryfogle J, Labonte JW, Krys J, RosettaCommons Consortium (including McShan AC), Bystroff C, Schief W, Gront D, Schueler-Furman O, Baker D, Bradley P, Roland Dunbrack R, Kortemme T, Leaver-Fay A, Strauss CE, Meiler J, Kuhlman B, Gray JJ, and Bonneau R. Better together: Elements of successful scientific software development in a distributed collaborative community. PLoS Comput Biol. 16(5):e1007507, 2020 [read]


16. Wei KY, Moschidi D, Bick MJ, Nerli S, McShan AC, Carter LP, Huang PS, Fletcher DA, Sgourakis NG, Boyken SE, Baker D. Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. PNAS, 117(13):7208-7215, 2020 [read]


15. Park J, Selvaraj B, McShan AC, Boyken SE, Wei KY, Oberdorfer G, DeGrado W, Sgourakis NG, Cuneo MJ, Myles DA, Baker D. De novo design of a homo-trimeric amantadine-binding protein. eLife, 8. pii: e47839, 2019 [read]


14. McShan AC*, Devlin CA*, Overall SA, Park J, Toor JS, Moschidi D, Flores-Solis D, Choi H, Tripathi S, Procko E#, Sgourakis NG#. Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection. PNAS, 116(51):25602-25613, 2019 [read]


13. Marceau AH*, Brison C*, Nerli S*, Arsenault HE, McShan AC, Chen E, Lee HW, Benanti JA, Sgourakis NG, Rubin SM. An order-to-disorder structural switch activates the FoxM1 transcription factor. eLife, 8. pii: e46131, 2019 [read]


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12. Marcos E, Chidyausiku TM, McShan AC, Evangelidis T, Nerli S, Carter L, Nivon LG, Davis A, Oberdorfer G, Tripsianes K, Sgourakis NG, Baker D. De novo design of a non-local β-sheet protein with high stability and accuracy. Nat Struct Mol Biol., 25(11):1028-1034, 2018 [read]


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11. McShan AC, Natarajan K, Kumirov VK, Flores-Solis D, Jiang J, Badstubner M, Toor JS, Bagshaw CR, Kovrigin EL, Margulies DH, Sgourakis NG. Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle. Nat Chem Biol., 14(8):811-820, 2018 [read]


10. Natarajan K, Jiang J, May NA, Mage MG, Boyd LF, McShan AC, Sgourakis NG, Bax A, Margulies DH. The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling. Front Immunol., 9:1657, 2018 [read]


9. Nerli S, McShan AC, Sgourakis NG. Chemical shift-based methods in NMR structure determination. Progress in Nuclear Magnetic Resonance Spectroscopy, 106-107, 2018 [read]


8. Toor JS, Rao AA, McShan AC, Yarmarkovich M, Nerli S, Yamaguchi K, Madejska AA, Nguyen S, Tripathi S, Maris JM, Salama SR, Haussler D, Sgourakis NG. A Recurrent Mutation in Anaplastic Lymphoma Kinase with Distinct Neoepitope Conformations. Front Immunol., 9:99, 2018 [read]


7. Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG. An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role. Nat Commun., 16;8:15260, 2017 [read]


Publications while at Genentech (Wang lab)


6. McShan AC, Kei P, Ji JA, Kim DC, Wang YJ. Hydrolysis of Polysorbate 20 and 80 by a Range of Carboxylester Hydrolases. PDA J Pharm Sci Technol., 70(4):332-45, 2016 [read]


Publications while at the University of Kansas (De Guzman lab)


5. McShan AC, Kaur K, Chatterjee S, Knight KM, De Guzman RN. NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions. Proteins, 84, 1097-1107, 2016 [read]


4. McShan AC, Anbanandam A, Patnaik S, De Guzman RN. Characterization of the Binding of Hydroxyindole, Indoleacetic acid and Morpholinoaniline to the Salmonella Type III Secretion System Proteins SipD and SipB. ChemMedChem, 11, 963-971, 2016 [read]


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3. McShan AC, De Guzman RN. The bacterial type III secretion system as a target for developing new antibiotics. Chem Biol Drug Des., 85(1):30-42, 2015 [read]


2. Rathinavelan T, Lara-Tejero M, Lefebre M, Chatterjee S, McShan AC, Guo DC, Tang C, Galan JE, De Guzman RN. NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. J Mol Biol., 12;426(16):2958-69, 2014 [read]


1. Chatterjee S, Chaudhury S, McShan AC, Kaur K, De Guzman RN. Structure and biophysics of type III secretion in bacteria. Biochemistry, 52(15):2508-17, 2013 [read]


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structure gallery.


Below is a gallery of structures solved by our lab, either independently or through collaborative efforts with other labs. We love to solve macromolecular structures because they inform scientists of biological function, provide important insights into disease, and open new avenues for drug development.

You must have WebGL enabled to view the structures

3Dmol is used for visualization.
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Ac-6-FP/MR1/TAPBPR structure - PDB ID 7RNO
Solved while in the Sgourakis lab (UPENN/CHOP)
Function: Metabolite antigen presentation


NRASQ61K/HLA-A*01:01 structure - PDB ID 6MPP
Solved in the Sgourakis Lab together with David Flores-Solis (UC Santa Cruz)
Function: Neoepitope antigen presentation in neuroblastoma


Computationally designed protein XAA - PDB ID 6O0I
Solved in the Sgourakis lab together with Danai Moschidi and Santrupti Nerli (UC Santa Cruz)
Collaboration with Kathy Wei in the Baker lab (UW)
Function: De novo designed protein


Disulfide linked P18-I10/H2-Dd - PDB ID 6NPR
Solved in the Sgourakis lab together with Joey Toor and Sarvind Tripathi (UC Santa Cruz)
Function: Peptide antigen presentation


FoxM1 transcription factor - PDB ID 6OSW
Solved in the Sgourakis Lab together with Santrupti Nerli (UC Santa Cruz)
Collaboration with Aimee Marceau in the Rubin lab (UC Santa Cruz)
Function: Cancer associated transcription factor


De novo designed double-stranded beta-helix - PDB ID 6E5C
Solved in the Sgourakis Lab together with Santrupti Nerli (UC Santa Cruz)
Collaboration with Enrique Marcos in the Baker lab (UW)
and Thomas Evangelidis in the Tripsianes lab (CEITEC)
Function: De novo designed protein
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resources.


Scripts and software developed by our lab will be shared in the future! Stay tuned.

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learn.


Below are resources to learn about macromolecule structures and the experimental techniques commonly used by our lab.

*The CD1 family: serving lipid antigens to T cells since the Mesozoic era introduction to CD1

* 5 challenges we could solve by designing new proteins by David Baker

* AlphaFold: The making of a scientific breakthrough

*iBiology interesting and state-of-the-art science lectures

*Ask a Scientist Gaming hosted by Kenneth Hanson where video games and science collide

*ICMBRS Webinars biomolecular NMR lectures

*Protein Folding and Dynamics Webinars lectures on protein folding and dynamics

*Global NMR Discussion Meetings biomolecular NMR lectures

*Getting Started in Cryo-EM tutorial by Grant Jensen

*Basics of Macromolecular Crystallography by Andrea Thorn

*Learn Rosetta computational biomolecular modeling tutorials

*Walter Bauer nmr spectroscopy meets music

*Frank Delaglio lecture on nmr processing in nmrpipe

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teaching.



Fall 2022 - CHEM 6501 - Biochemistry I

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fun.


Here are fun resources we've compiled over the years. A lot of it focuses on how science, math, and art can integrate together to elucidate the beauty of nature. We hope you find something that sparks your interest.

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*3D-XplorMath. open source software for topological surface visualization virtual math museum gallery of shapes and surfaces made using 3D-XplorMath *46 billion pixel panorama image of the Milk Way galaxy astronomy

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*Susan Aldworth website science based art, illustration, etching, mixed media *Rafael Araujo website math based art, illustration, landscapes *art for science science journal and book illustrations

b:

*BALLView website biomolecular visualization software *Michele Banks website science based art, biology, watercolor, collage *Tom Beddard website math based art, fractals, 3D *Drew Berry Bjork - Hollow 3d biology animation for a Bjork video *Luc Benard collaboration with Richard Palais *BioBlender open source software for 3D rendering with science applications *Paul Bourke website math based art, simulations, etc. *Caroline Bowen website math and physics based art *Kelsey Brookes website science based art, biochemistry, pop, abstract, psychedelic *Roger Brown website science based art, paper sculptures

c:

*Santiago Calatrava website science and math based architecture and engineering, ceramics, sculpture, drawings *Jonathan Callan website using books and paper as a sculptural medium *Alexander Calder website sculpture, abstract Calder and abstraction: from avant-garde to iconic *Joey Camacho website science based art, 3D motion and graphic design *Camila Sitarama Carlow website science based art, nature, mixed media *George F. Chambers list of books as pdf vintage astronomy illustrations *Chaoscope website software for math based rendering and dynamic systems *Julie Alice Chappell website science based art *Chemistry in pictures website science, photography *William Chyr website science based art, sculpture, balloons *Andreas Cellarius some of his works vintage astronomy illustrations, cartography check out Harmonia Macrocosmica *Chemical Bouillon website science based art, chemical reactions, video, patterns and abstract shapes *Dale Chihuly website abstract, glass work *Caleb Charland website abstract *Anita Chowdry website math based art, paper sculptures, abstract, etching, geometry *Francesco de Comite website math based art, geometry, 3D printing flickr *Jean Constant website math based art, topology *Justine Cooper website science based art *Pedro Cruz website science based art, creative coding, generative art

d:

*Erik Demaine website math based art, geometry, origami *Maja Divjak vimeo science based art, molecular movies, 3D *Katharine Dowsen website science based art, sculpture, glass work *Greg Dunn website science based art, neuroscience, etching, scrolls

e:

*James R. Eads website abstract, illustration *Maria Clara Eimmart some examples vintage astronomy illustrations *Olafur Eliasson website sculpture, light/color *M.C. Escher website math based art, abstract, multimedia *Engineering at Cambridge University flickr science based art and photography, check out their photography competitions *EteRNA RNA folding game, software

f:

*Sarah Featon website scientific illustration, botany *Fold It! biochemistry and protein folding game, software *Anatoly Fomenko website math based art, abstract *Lucio Fontana artsy abstract, painting, graphic design *R. Buckminster Fuller artsy architecture, geometry, engineering

g:

*Fred Gambino website science fiction, concept design, animation *Eleanor Gates-Stuart website science based art *Giant Microbes science based art, plush microbes *Steve Gildea website science based art, space art, painting, drawing, 3D *Linden Gledhill website science based art, abstract *Andy Goldsworthy visual melt science based art, nature, symmetry *David Goodsell website science based art, biology illustrations, proteins and organisms *Akinori Goto tumblr media art *Bathsheba Grossman website science based art, sculpture, laser crystals, glass work

h:

*Ernst Haeckel art forms in nature vintage biology illustrations *Bradford Hansen-Smith website math based art, sculpture, paper sculpture *George W. Hart website math based art, sculpture, design *Stuart Haygarth website math based art, sculpture, abstract *HEBOCON HEBOCON: The Robot Contest for Dummies engineering *Patrik Huebner website math based art, creative coding, generative design *Jonty Hurwitz website science and math based art, abstract, nanosculptures

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*Iconographic Encyclopedia of Science, Literature and Art vintage science illustrations * The Institute For Figuring website creative engagements with topology, physics, computation and biology crochet coral reef crochet, marine biology *Interactions Image Bank website image databank of physics stuff. particle collision images are particularly beautiful. *Ig Nobel Prize abstract and interesting research

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*Wenzel Jamnitzer BibliOdyssey vintage math based art, symmetry, etching *Christopher Janney website math based art, architecture, sound *Luke Jerram website science based art, biology, glass work, multimedia *Brian Johnston views through a mathematical microscope of some 3D oddities *Janusz Jurek website math based art, illustration, sculpture behance

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*Markos R. Kay website science based art, 3d motion graphics, simulations, prints check out aDiatomea *Ikumi Kayama website science based art, illustration *Alexey Kashpersky website science based art, digital art, 3D, photography *Dinara Kasko website architectural, geometry, gastronomy *Melanie Kathryn-King website science based art, illustration, photography *Charles Knight website vintage biology art, dinosaurs *Stephen R. Kutcher website science based art, art using insects, painting *Martin Krzywinski website science based art, data visualization

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*Robert J. Lang website origami *Kenneth Libbrecht website science based art check out snow crystals *Emma Lindstrom website painting *Richard Long website math and science based art, nature, symmetry, sculpture, drawing *Lorem Ipsum tumblr creative coding, generative art, abstract *Marcus Lyon website design, photography *Eleanor Lutz website scientific illustration

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*Benoit Mandelbrot Mandelbrot set. fractals, geometry *Friedrich Heinrich Wilhelm Martini shell prints vintage science illustration *Oliver Marsden website math based art, abstract, painting, illustration, prints *melodysheep Symphony of science science topic based music check out a glorious dawn a tribute to carl sagan *Nathalie Miebach website science art, abstract, music, sculpture *Steve Miller website science based art, sculpture, painting *Hine Mizushima website science based art, felt *Anne Mondro website sculpture

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*NASA science NASA project apollo archive space photography astronomy picture of the day large library of space photography *Neurobureau brain art gallery science based art, neuroscience *Odra Noel Odra Noel science based art *Nikon Small World in Motion youtube channel science based art, microscopy, photography *Paul Nylander website math and physics based art

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*Nuala O'Donovan website math based art, sculpture, ceramics, abstract *Fabian Oefner website science based art, paint, multimedia *Neri Oxman website science based art, 3d printed fashion, sculpture

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*Pacific Northwest National Laboratory flickr check out their science as art section *Kate Patterson youtube science based art, molecular movies, 3D *J. C. Park website science fiction, concept, design *Sui Park website sculpture *The Particle Zoo website science based art, plush dolls of fundamental particles, particle physics *Princeton University art as science galleries *Processing open source software for creative coding and generative art open processing sharing of sketches and code made using Processing *PyMol open source software for 3D visualization and rendering of proteins and molecules *Helen Pynor website science based art, sculpture, illustration

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*Sabine Reckewell website design, sculpture *Ribosome dance Protein synthesis: an epic on the cellular level biochemistry *Jane S. Richardson Biophysical Highlights from 54 Years of Macromolecular Crystallography science illustration, biochemistry (particularly beta-sheet containing proteins) website *Michael Rigley website math and science based art, 3D, animation, design *Bridget Riley gallery of her works math based art, op art *Anthony Roussel website math based art, jewelry, digital art

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*Tomas Saraceno website math and science based art, architecture *SASJ website creative coding, generative art, geometry, shapes, game design *Science-Art databank of science based art, mostly nature and medical illustration *Nina Sellars website science based art, 3D *James B. Settles some of his works vintage science fiction illustrations *Alyson Shotz website math based art, architecture, sculpture *Oleg Soroko behance math based art, architecture, sculpture, abstract *Susi Sie website science and math based videos, abstract *JR Bee website science based illustration *Claudia Stocker website science based art, illustration *Nils Henrik Sundqvist website science based art, illustration, design, prints

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*P. G. Tait check out the 'On Knots' series vintage math illustrations, knot theory *Jared Tarbell website science and math based art, creative coding, generative art, photography flickr *Steve Tobin website math based art, sculpture, abstract, glass work, steel work *Anais Tondeur website science based art, space art, drawing

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*Julijonas Urbonas website engineering, math

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*Van Cleef & Arpels Midnight Planetarium timepiece astronomy, watch *Roman Verostko website math based art, illustrations, generative art *Arie van't Riet website science based art, photography, x-ray images *Julian Voss-Andreae website sculpture

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*Elise Wagner website science based art, painting, wax, abstract *WeatherStar 4000 simulator website meteorology, simulation *Wintergatan Marble Machine engineering, music

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y:

*Motoi Yamamoto website media art, installation

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*Doug Zongker chicken chicken chicken lecture what watching an academic lecture feels like sometimes what reading an academic paper feels like sometimes


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DEI values.


The McShan lab is committed to maintaining an inclusive research environment, regardless of age, gender, gender identity, sexual orientation, disability, race, religion, nationality, immigration status, or socio-economic background.

DEI
Our lab aims to help dismantle discriminatory structures inherent in academia by encouraging and promoting science done by diverse scientists, normalizing conversations about diverse journeys into science, and championing young scientists who don't fit into the outdated mold of who a scientist is. These efforts are personal to us as the McShan lab is run by a queer, non-binary scientist. You can read more about what it means to be a LGBTQAI+ scientist here. We also appreciate advocates and allies! We are grateful for Georgia Tech's commitment to diversity, equity, and inclusion (DEI).

At a minimum the McShan lab pledges to:


The poster and pledge have been derived from images and words by Sammy Katta.


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funding.


We are extremely grateful to the following funding institutions and agencies:

Georgia Tech's School of Chemistry and Biochemistry - Start up funds
GTBiochem


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join us.


We love to hear from anyone who is interested in our research. Previous experience in biochemistry is beneficial, but not required. All levels of experience are welcome!

We openly welcome members of the LGBTQAI+ community, women, disabled scientists (including those with invisible disabilities), and scientists of color.

Prospective graduate students should first apply to Georgia Tech's Chemistry and Biochemistry Graduate Program. You can apply here: Graduate Admission @ Georgia Tech's Chemistry and Biochemistry program. Accepted students should feel free to reach out and discuss opportunities in our lab.

Prospective Postdoctoral Fellows should send a cover letter and CV to andrew.mcshan@chemistry.gatech.edu. Your cover letter should address your primary career goals, your previous expertise, why you're interested in our work, and why you think our lab is a good fit for you.

Undergraduates and high school students interested in getting hands on experience with research should also reach out to us at andrew.mcshan@chemistry.gatech.edu

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contact.



Please contact us via e-mail at andrew.mcshan@chemistry.gatech.edu

The McShan lab is physically located in the Molecular Sciences and Engineering ("MoSE") building on the Georgia Institute of Technology campus in Atlanta, Georgia.

Office location: MoSE G022
Office Phone #: (404) 385-6052
Lab location: MoSE G125
901 Atlantic Drive NW
Atlanta, GA 30332-0400

Send USPS deliveries to:
Dr. Andrew McShan
901 Atlantic Drive NW
School of Chemistry and Biochemistry
Georgia Institute of Technology
Atlanta, GA 30332-0400

Send UPS and FedEx deliveries to:
Dr. Andrew McShan
311 Ferst Drive NW
School of Chemistry and Biochemistry
Georgia Institute of Technology
Atlanta, GA 30332-0400




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Georgia Institute of Technology
School of Chemistry & Biochemistry
Website design by Dr. McShan